Endocrine Abstracts

Background: The effect of weight loss on hypothalamic function is complex and not fully understood. There is interplay between neuropeptides (leptin, ghrelin) and hypothalamus with the postulated aim of energy conservation and prevention of pregnancy during unfavourable conditions. We present a memorable case.Case: A 35-yr-old lady presented with secondary amenorrhoea of 17 years duration. She attained menarche at age 13. At age 16 her periods became sca...